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Signed by Louis van Gaal for £29million in 2014, the Basque midfielder left United for PSG at the end of his contract but has failed to break into the side.
Injury has played a part, too, with the former Athletic Bilbao favourite having missed several weeks due to hamstring and thigh problems throughout his first season at the club.
His second year saw him feature more regularly.
In the twilight of his career, the Ecuadorian bid farewell to United 10 years after joining the club for £16million from Wigan Athletic.
A two-time Premier League winner, Valencia moved back to his native Ecuador with LDU Quito.
Since then, the right-back featured in Quito’s Copa Libertadores victory over 2018 champions River Plate.
In November 2020 he moved to Mexican side, Querétaro, where he announced his retirement from professional football in May.
Wilson joined Aberdeen last summer having spent the 2018/19 season at Pittodrie.
However, the striker failed to fire for the Dons and moved to Salford City on an 18-month contract in January.
The 24-year-old’s career with the League Two side started promisingly, too, with two goals on his debut in a 3-2 defeat by Plymouth Argyle, but couldn’t add to that tally before the season was put on hold.
His second season saw him flourish and he has since moved onto Port Vale.
With a solitary Europa League cameo to his name, Poole was not retained for the 2019/20 season.
After leaving Old Trafford, he joined MK Dons following the club’s promotion to League One.
And the Welshman has figured prominently under both Paul Tisdale and Russell Martin, and became a regular in the side.
He moved to Lincoln in January 2021 and has continued to play regularly.
After an unsuccessful loan spell at Port Vale, Whelan joined Watford following his release by United.
However, as he did at Vale Park, the 21-year-old central midfielder has struggled to make the matchday squad at Vicarage Road, with his two appearances both coming in the FA Cup.
He moved onto Oldham in 2020 where he has been given more opportunities and is a regular in the side.
Another player who failed to make the leap from the academy to the senior set-up at Old Trafford, Sang moved down a division to join Cardiff City.
The 20-year-old has yet to fully establish himself in Wales, though, making his debut in the club’s FA Cup penalty shootout defeat by Reading in February 2020.
He moved to Cheltenham last season but struggled for playing time there too.
Zak Dearnley Zak Dearnley
Despite having previously caught the eye for United’s Under-23s, Dearnley left Old Trafford last summer without a senior appearance to his name.
After a trial with Rotherham United, he had a brief spell with non-league side New Mills before joining Oldham Athletic, with whom he had a loan stint in 2019, in January.
The winger has found success at Boundary Park, with four goals in eight games for the League Two outfit and ended the 2020/21 campaign with seven goals.
Another to have starred at youth level for United, Buffonge joined Serie B side Spezia after trials with Derby County and Bolton Wanderers.
The midfielder has since dropped down another level, to Serie C, with Pergolettese on loan. He hasn’t found success in Italy and is now with NAC Breda in the Netherlands.
At one stage considered a bright defensive prospect at United, Warren left in 2019 having struggled to sufficiently live up to his potential.
After an unsuccessful trial at Bolton, he joined Salford City before joining non-league Radcliffe in October. He returned to Salford and moved to Halifax this summer.
In the 2016/17 season, Willock was on the cusp of breaking into Louis van Gaal’s United side.
Twice an unused substitute in Premier League games, that was the closest the midfielder would get to fulfilling his dream of playing for the Reds.
After several loan spells during the last two years of his time at Old Trafford, Willock joined Gillingham last summer. He caught the eye there and moved to Salford this summer where he scored on his debut.
Having arrived from New York Red Bulls in 2016, Olosunde trained and travelled with Solskjaer’s first-team squad during the latter stages of the 2018/19 season before being released last summer.
The one-time United States international was quickly snapped up by Rotherham United, where he has been a hit, making 32 appearances in his first term.
This summer he was able to make the step-up to the Championship joining Preston.
Once one of the highest-rated youngsters at United, injuries ravaged Gribbin’s progress before he failed to make 2019’s retained list.
However, he was handed a Premier League lifeline last summer by newly-promoted Sheffield United.
The 21-year-old did not feature for the Blades. He moved to Barrow last summer but made just one league appearance and was released this summer.
A much-hyped arrival from Ajax in 2017, Baars failed to make the grade at United before joining the long list of released players in 2019.
After several months without a club, Baars signed a two-year contract with AZ Alkmaar at the start of May 2020 but he is yet to make his debut for the club’s first team.
Having honed his skills in the academies of Brentford and United, Bohui was released in 2019 having previously rejected a contract offer by the Old Trafford club.
The young forward decided to try and rejuvenate his career in the Netherlands with second-tier side NAC Breda. He did not make the grade there and moved to Colchester where he struggled to break into the side and was released by the club this summer.
Thompson was released after having featured for United’s Under-18s and has been without a club since leaving United in June 2019.
Once highly rated, Mitchell failed to make the grade at United after a serious injury curtailed his career during his time on loan with Hearts.
He moved onto Blackpool when he was released in 2020 where he has been able to feature regularly and has looked back to his best.
A product of the Fletcher Moss Rangers academy who discovered the likes of Jesse Lingard and Marcus Rashford, Borthwick-Jackson was highly rated at the club.
He made 14 first team appearances and spent time on loan in the Championship.
However, over the years his development stagnated and he moved further down the ranks. He was ultimately released in 2020 and made a permanent move to Oldham Athletic where he has featured regularly.
Hamilton never made a senior appearance for Manchester United, but he had some good moments in the club’s academy.
He caught the eye in loan spells with Rochdale, Southend and Bolton before being released by the club.
Peterborough were happy to take him up and he has settled into the side making 34 appearances in his first season.
The attacking midfielder caught the eye at times for the club’s U18 side but he struggled to make the step-up.
A technically gifted player, McGhee was released by United in the summer of 2020.
He spent six months without a club before joining Braga where he has not yet played for the club’s first team.
The highly rated youngster was impressive for the club’s academy and United were open to extending his deal, but Ramazani opted to leave for pastures new.
He joined Spanish side Almeria where he has made 15 league appearances and scored two goals.
Ramazani will be hoping to build on his debut season this time around.
The Blackpool born full-back was a product of the club’s academy and caught the eye whilst on loan at Morecambe. But his loan spell with Salford was disappointing.
Which meant it was no surprise when the club released him in the summer of 2020.
He settled in well moving to Carlisle where he featured in 37 league games during his debut season.
Highly rated Barlow represented England at youth level and United had big hopes for the attacking midfielder.
Barlow went on-loan to Tromso in Norway but did not show enough for United to extend his contract and was released upon its expiry.
He was without a club for a year, but he caught the eye on trial with Doncaster Rovers and earnt himself a permanent move.
The Irish goalkeeper spent seven different loan-spells whilst at United.
He was ultimately released in 2020 and moved onto Burton Albion where he spent his final loan-spell at United.
Since making his switch to Burton a permanent one he has continued to feature regularly for the League One side.
The Slovakian goalkeeper came to United after being scouted in his homeland. He was a regular at U18 level and made a few appearances in the U23s before moving on-loan to Stalybridge.
However, it was not enough to impress the United coaches.
Fojticek was released in 2020. He moved onto Blackpool but struggled to get into the side and made no appearances for the first team before moving back to Slovakia to join second tier outfit Partizan Bardejov.
The Portugal U21 goalkeeper spent nine years at the club making only just three appearances for United’s first team.
In total Pereira had six different loan spells away from Old Trafford before he was released by the club this summer.
He has joined RKC Waalwijk in the Eredvisie and it looks like he will be a regular for the Dutch side.
At times Romero was an outstanding deputy to David de Gea. The Argentine was instrumental in United’s Europa League victory back in the 2016/17 season.
However, he fell to third choice in the pecking order after the emergence of Dean Henderson and it was no surprise to see him released this summer after Romero failed to make an appearance in his last season at the club.
The Argentine is yet to find a new club.
The academy goalkeeper caught the eye in the Northern Irish Premier League during his final loan spell at Old Trafford.
Carney was a solid stopper at U18 level but he was never first choice even at the academy.
After being released this summer, Carney has joined Sunderland where he has initially linked up with the club’s U23 team.
The midfielder was highly rated by the club’s academy and caught the eye at both U18 and U23 level.
However, Helm chose to set out on a new challenge this summer after he did not renew his contract with United.
The 19-year-old has moved to Burnley where he will be hoping to follow suit of Dwight McNeil.
The Welsh youth international came through the ranks at United.
He was impressive for the club’s U18 side making three assists in 24 appearances as a full-back.
But United decided not to renew his deal and Hughes moved onto Leicester City once his contract expired. He started the club’s first U23 game of the season against United.
The Spaniard was brought in from Espanyol despite interest from several other European giants.
Puigmal always caught the eye during his time in the club academy.
He scored six goals and registered three assists in nine appearances for the club’s U23 side last season, but was released after not seeing a pathway into the club’s first team.
Puigmal joined Almeria in La Liga where he will be hoping to get the regular playing time he feels he deserves.
The United centre-back was highly rated by academy staff but a pathway to the first team was always unlikely.
He was well liked at the club, and many rallied behind him after he underwent a cancer diagnosis for testicular cancer.
Taylor made a full-recovery. He has joined Rochdale since leaving United and has been a regular at the club so far.
The exciting PSG academy graduate arrived with high hopes.
He caught the eye in glimpses at the club’s academy. Enough to spend last season on-loan at French Ligue 2 outfit Caen.
And while Traore was a regular there, he did not do enough for United to retain him this summer with the club releasing the French youth international.
Traore is yet to find a club.